Current Issue : October-December Volume : 2021 Issue Number : 4 Articles : 3 Articles
The present study examined the antioxidant activity of the ethanolic extract from the egg mass of C. catla. The ethanolic extract of egg mass showed the total antioxidant activity of 13.89 - 53.71% at 50 – 250 µg/ml concentration. The DPPH radical scavenging activity of ethanolic extract from the egg mass of C. catla recorded 15.03 - 49.58% at 50 – 250 µg/ml concentration. The ABTS radical scavenging activity of ethanolic extract from the egg mass of C. catla showed 18.01 - 62.59% at 50 – 250 µg/ml concentration. The inhibitory effect of ethanolic extract from the egg mass of C. catla on superoxide radical damage was 20.61 - 65.02% at 50 – 250 µg/ml respectively. The effect of ethanolic extract from the egg mass of C. catla on oxidative damage induced by hydroxyl radical at different concentrations 50 – 250 µg/ml were found between 19.35 and 58.91% respectively . Above results of the antioxidant activity of the ethanolic extract from the egg mass of C. catla can helpful to human health and may preventive effect in some diseases....
In this investigation, Swiss albino mice were used to assess the preventive effectiveness of Artocarpus heterophyllus extract against peroxidative damage that contributes to skin carcinogenesis. A single topical treatment of 7,12-dimethyl benz(a)anthracene (100 microg/100 microl acetone), followed two weeks later by recurrent application of croton oil (1 percent in acetone three times a week) and continued until the conclusion of the experiment (i.e. 16 weeks), resulted in a 100% tumour incidence. Mice treated with the Artocarpus heterophyllus extract (200 and 400 mg/ kg/ b.wt./ animal /day) in the peri (i.e. 7 days before and after the application of DMBA) or post-initiation (i.e. from the day of croton oil treatment and continued until the end of the experiment) phases showed significant reductions in cumulative numbers of papillomas and tumour incidence (75 percent). In comparison to the carcinogen control group, the average latency duration in the Artocarpus heterophyllus extract treated group was substantially longer (Pre Group - 14 weeks; Post Group - 16 weeks). Results from the present study indicate that the anticarcinogenic activity of Artocarpus heterophyllus extract during DMBA-induced skin papillomagenesis is mediated through alteration of antioxidant status. Thus, Artocarpus heterophyllus extract can be considered as a readily accessible, promising novel cancer chemo-preventive agent....
Butea monosperma is a small to medium sized tree extensibly used in Ayurveda, Unani and Homeopathic medicine and has become a cynosure of modern medicine. Butea monosperma is used as tonic, astringent, aphrodisiac and diuretics etc. The aim of present study was to evaluate anti-epileptic activity of butanolic extract of leaves of Butea monosperma against electroshock induced convulsions in mice. All the animals were divided into four groups of six mice each for electroshock induced convulsions study. To induce convulsions in animals, the electroshock is induced in animal by passing a current of 50 mA respectively. In each study, Group I was served as toxic control, group II was treated with phenytoin (20 mg/kg intraperitorially). Group III and group IV will be treated with Butea monosperma (100mg/kg p. o.) and (200mg/kg p. o.) respectively. The result shows that butanolic extract of leaves of Butea monosperma reduced duration of convulsion and also delayed the onset of convulsions induced by maximal electroshock. The results were expressed as mean±SEM and were statistically analyzed by one way ANOVA. It is concluded that butanolic extract of leaves of Butea monosperma showed antiepileptic activity against electroshock convulsions in mice and reduced mortality....
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